Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus.

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Mild hypothermia ameliorates ubiquitin synthesis and prevents delayed neuronal death in the gerbil hippocampus.

BACKGROUND AND PURPOSE The purpose of the present study is to determine the effect of mild hypothermia on the synthesis of ubiquitin, an important protein for maintenance of cell viability, in the hippocampal neurons following transient cerebral ischemia. METHODS Transient ischemia was induced by occluding both common carotid arteries for 5 minutes. In experiment 1, the animals were divided i...

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ژورنال

عنوان ژورنال: Stroke

سال: 1991

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.22.12.1574